Bioelectrical impedance

BIOLECTRICAL IMPEDANCE:RELATIONSHIP AMONG CAPACITANCE, CELL AGEING AND TOXIC METAL INTOXICATIONS

European Journal of Integrative Medicine 4:198   September 2012 DOI: 10.1016/j.eujim.2012.07.940 

Proietti Maurizio 1, Bonucci Massimo 2, Del Buono Andrea 3, D’Orta Armando 3,
1 Associazione Italiana Studio Elementi Tossici (A.I.S.E.T.); 2 Casa di Cura San Feliciano, Rome; 3 Accademia di Micronutrizione ‘L. Pauling’, Caserta;  Italy

The membrane potential (E) produced by a given net charge in the cell (Q) depends on the physical properties of the cell membrane, summarised by a constant called ’capacitance’ (C) E = Q/C. The capacitance depends on the area of the membrane, the thickness and the K dielectric. A large capacitance means that, in order to modify the membrane potential, many ions have to be moved. The C for the cell membranes is about 1F cm–2.
The cell membrane contains a precise ratio of polyunsaturated and saturated fatty acids. Maintaining this equilibrium favours the steric adaptation of membrane proteins in order to maintain the electrical potential of the membrane. The membrane itself becomes similar to a liquid crystal semiconductor, equipped with ports and channels, that is the equivalent structure and function of a silicon chip. This particular similarity allows us to understand how the membrane may also relate to the environment
with non-chemical mediators. During the last years of our activity, we have observed, as ’case reports’, in patients with chronic neurodegenerative diseases, a clear alteration of the membrane capacitance. The data analysed, in our opinion, are interpreted as an index of alteration of the cell membrane; on the other
hand, if we plan a good chelation/detoxification treatment, this parameter returns to the physiologic range. The data we observed are highly correlated with the presence of toxic minerals in the body. A reduction of toxic minerals in the food or in the air we breathe could lead to the decrease of chronic neurodegenerative disease. This analysis deserves more attention from the experts of neurotoxicity.